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Optimum Nutrition Micronised Creatine Powder, 100% Pure Creatine Monohydrate Powder for Performance and Muscle Power, Unflavoured Shake, 93 Servings, 317 g

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There are claims for a number of uses, some of which are supported by research evidence. Improving athletic performance DHT is a metabolite of testosterone, formed when the enzyme 5-alpha-reductase converts free testosterone to DHT [ 63]. In males, DHT can bind to androgen receptors in susceptible hair follicles and cause them to shrink, ultimately leading to hair loss [ 64]. However, in the van der Merwe et al. [ 61] study, no increase in total testosterone was found in the 16 males who completed the study. Free testosterone was not measured. Moreover, the increase in DHT and the DHT: testosterone ratio remained well within normal clinical limits. Furthermore, baseline (prior to supplementation), DHT was 23% lower in the creatine group (0.98 nmol/L) compared to the placebo group (1.26 nmol/L). Thus the small increase in DHT in the creatine group (+ 0.55 nmol/L after 7 days of supplementation and + 0.40 nmol/L after 21 days of supplementation), in combination with a small decrease in the placebo DHT response (-0.17 nmol/L after 7 days of supplementation and -0.20 nmol/L after 21 days of supplementation) explains the “statistically significant” increase in DHT noted by van der Merwe et al. [ 61]. While it is possible that creatine supplementation upregulated 5-alpha-reductase activity in these males (potentially leading to increased formation of DHT), no study has reported hair loss/baldness in humans. Muscle cramps: ‘In rare cases, creatine supplementation may cause muscle cramps or strains. Staying well-hydrated and ensuring proper electrolyte balance can help prevent these issues,’ says Aitken. An animal study involving a combined treatment of coenzyme Q(10) and creatine concluded that this might help treat neurodegenerative diseases such as Parkinson’s disease and Huntington’s disease.

After that initial retention period, subsequent gains are due to the increase in the workload you can handle, according to Paul Greenhaff, Ph.D., professor of muscle metabolism at the University of Nottingham in England. Creatine has different effects on every individual. Some people just don’t respond to creatine—it’s a genetic thing. Paige, N. M., et al. (2009). The top 10 things nephrologists wish every primary care physician knew.In a study, 1 week of high dose loading of creatine supplementation (20 grams/day) increased participants’ body weight by around 2–6 pounds (1–3 kg) ( 10). To be safe, he recommends using creatine only if you are healthy and have no kidney problems. That’s because your kidneys excrete creatinine, a breakdown product of creatine. Creatinine is a blood chemical waste product made when you use muscles. Learn about home remedies to naturally lower your creatinine levels. READ MORE However, many scientists believe more study of creatine needs to be done. Most studies of creatine have included only 40 people at the most, and these participants weren't representative of all athletic abilities or ages, according to the U.S. Department of Health and Human Services National Institutes of Health. Creatine has not been effective at improving endurance and aerobic performance in most studies. People in the early stages of Parkinson's diseasemay see a benefit from taking creatine. In a study of 20 Parkinson's patients, people who were taking creatine supplements made better gains over 24 sessions of an upper-body strength conditioning program compared with people who took a placebo, according to the 2007 paper published in the journal Neurorehabilitation and Neural Repair. Other preliminary studies showed creatine supplements slightly improved mood in Parkinson's patients, and may slow progression of the disease in early stages.

Powder is the way to go. Studies show that liquid creatine and creatine ethyl ester (CEE) are unstable and break down in your blood system. Don’t bother with them.

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Cramping, stomach pain, nausea and diarrhea are the most commonly reported side effects from taking creatine supplements. Creatine may cause muscles to retain water, but professional sports nutrition and medical associations are split on whether there is enough scientific evidence to link creatine to excess water weight. There have also been reports of dehydration and muscle strains while taking creatine, according to a joint statement by the American Dietetic Association, Dietitians of Canada and the American College of Sports Medicine. The joint statement recommended that professionals carefully screen athletes for potential kidney or liver problems before starting a creatine regimen. Likewise, if the increased creatinine levels are due to high blood pressure, taking medication to treat this should also lower creatinine levels.

If you've started taking creatine, you should know if it works for you in about a week. If your training volume increases, it’s working for you. If not, you’re probably a non-responder, and taking the powder isn’t going to help you. Many people with high blood pressure experience no symptoms, and doctors may only detect the issue during a regular health screening. Heart disease Researchers are constantly studying creatine for its effectiveness and safety. That’s why many trainers and health experts support the use of creatine: Studies indicate it’s safe.

Taking creatine supplements for up to 8 years has been shown to improve attention, language and academic performance in some children. However, it does not affect everyone in the same way. Antibiotics, cardiovascular drugs, diuretics, and some other medications can cause kidney damage and affect how well the kidneys function. Some claim it causes weight gain, cramping, and issues with digestion, the liver, or the kidneys. But hundreds of studies support its safety and effectiveness.

Creatine contains no calories, and has no impact on your fat metabolism," he says. "So taking creatine and not working out is just going to lead to nothing." https://www.niddk.nih.gov/health-information/urologic-diseases/kidney-infection-pyelonephritis/symptoms-causes However, according to the U.S. National Library of Medicine, creatine does not build muscle. The increase in body mass occurs because creatine causes the muscles to hold water. In summary, experimental and controlled research indicates that creatine supplementation, when ingested at recommended dosages, does not result in kidney damage and/or renal dysfunction in healthy individuals. Does creatine cause hair loss / baldness?It is transported through the blood and used by parts of the body that have high energy demands, such as skeletal muscle and the brain. In summary, while there is some evidence to suggest that creatine supplementation increases water retention, primarily attributed to increases in intracellular volume, over the short term, there are several other studies suggesting it does not alter total body water (intra or extracellular) relative to muscle mass over longer periods of time. As a result, creatine supplementation may not lead to water retention. Is creatine an anabolic steroid? Short- and medium-term creatine treatment improves muscle strength in people with muscular dystrophies and is well-tolerated.” In South Korea, 52 women with depression added a 5-gram creatine supplement to their daily antidepressant. They experienced improvements in their symptoms as early as 2 weeks, and the improvement continued up to weeks 4 and 8. Using creatine every day for 8 to 16 weeks may improve muscle strength and reduce fatigue in people with muscular dystrophy, but not all studies have produced the same results. Parkinson’s disease

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